| Identification | Back Directory | [Name]
2H-1,5-Benzoxathiepin-3-amine, 3,4-dihydro-N-[(2S)-3-[(2-methoxyphenyl)thio]-2-methylpropyl]-, (3R)- | [CAS]
470454-73-0 | [Synonyms]
F15845
2H-1,5-Benzoxathiepin-3-amine, 3,4-dihydro-N-[(2S)-3-[(2-methoxyphenyl)thio]-2-methylpropyl]-, (3R)- | [Molecular Formula]
C20H25NO2S2 | [MOL File]
470454-73-0.mol | [Molecular Weight]
375.55 |
| Hazard Information | Back Directory | [Uses]
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment[1]. | [in vivo]
F 15845 (i.v.; 5 mg/kg) exhibits remarkable cardioprotective properties in anesthetized rat[1]. | Animal Model: | Rat[1] | | Dosage: | 2.5 mg/kg, 5 mg/kg | | Administration: | intravenously | | Result: | Significantly reduced infarct size, decreased of troponin I levels and limited the long-term expansion of infarct size. |
| [References]
[1] Bruno Vié, et al. 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate (F 15845) prevents ischemia-induced heart remodeling by reduction of the intracellular Na+ overload. J Pharmacol Exp Ther. 2009 Sep;330(3):696-703. DOI:10.1124/jpet.109.153122 |
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