| Identification | Back Directory | [Name]
ADDA 5 hydrochloride | [CAS]
473268-46-1 | [Synonyms]
ADDA-5)
ADDA 5 HCl
ADDA 5
(ADDA5
ADDA 5 hydrochloride
ADDA 5 hydrochloride >=98% (HPLC) | [Molecular Formula]
C24H36ClNO2 | [MDL Number]
MFCD02053515 | [MOL File]
473268-46-1.mol | [Molecular Weight]
406.01 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 65 mg/mL (160.10 mM) | [form ]
Solid | [color ]
White to off-white | [SMILES]
OC(CN1CCC(C=CC=C2)=C2C1)COCCC34C[C@H]5C[C@H](C[C@H](C5)C4)C3.[H]Cl |
| Hazard Information | Back Directory | [Uses]
ADDA 5 hydrochloride has been used as a complex IV inhibitor to study its effects on leptomeningeal derivatives of human breast and lung cancer cells. | [Biological Activity]
ADDA 5 is a potent and selective inhibitor of cytochrome c oxidase (Complex IV) th at depletes the bioenergetics reserve capacity in intact glioma cells. ADDA 5 specifically inhibits the proliferation of chemosensitive and chemoresistant glioma cellswhile sparing non-cancer cells. Additionally ADDA 5 is effective against glioma stem cells. | [in vivo]
ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1]. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|