| Identification | Back Directory | [Name]
Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- | [CAS]
474432-65-0 | [Synonyms]
FAUC 346
Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- | [Molecular Formula]
C24H29N3O2S | [MDL Number]
MFCD34179561 | [MOL File]
474432-65-0.mol | [Molecular Weight]
423.57 |
| Chemical Properties | Back Directory | [Melting point ]
137-139 °C | [Boiling point ]
656.5±55.0 °C(Predicted) | [density ]
1.190±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (236.09 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.55±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM)[1][2]. | [Biological Activity]
FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior[1][2].
FAUC 346, an in vitro D3-selective ligand with a Ki of 0.23 nM in CHO cells for D3 receptor[1].FAUC346 shows some affinity for 5HT1A receptors (Ki = 41 nM) and for α1 receptors (Ki = 15 nM)[1]. | [IC 50]
D3 Receptor: 1.5 nM (EC50) | [References]
[1]. Bertrand Kuhnast, et al. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide -- a potential radiotracer for D3 receptor imaging with PET. Nucl Med Biol. 2006 Aug;33(6):785-95. [2]. Carsten Hocke, et al. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem. 2008 May;3(5):788-93. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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