| Identification | Back Directory | [Name]
desmethylazelastine | [CAS]
47491-38-3 | [Synonyms]
Azelastin IMP
Demethylazelastine
desmethylazelastine
Azelastine Impurity 6
N-Desmethyl Azelastine
Azelastine Hydrochloride Impurity
N-Desmethyl Azelastine (1.0mg/ml in DMSO)
4-(p-Chlorobenzyl)-2-[(hexahydro-1H-azepin)-4-yl]phthalazin-1(2H)-one
4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1H-azepin-4-yl)-1(2H)-phthalazinone
N-desmethyl AzelastineQ: What is
N-desmethyl Azelastine Q: What is the CAS Number of
N-desmethyl Azelastine Q: What is the storage condition of
N-desmethyl Azelastine
N-desmethyl Azelastine D4Q: What is
N-desmethyl Azelastine D4 Q: What is the CAS Number of
N-desmethyl Azelastine D4 Q: What is the storage condition of
N-desmethyl Azelastine D4 Q: What are the applications of
N-desmethyl Azelastine D4 | [Molecular Formula]
C21H22ClN3O | [MDL Number]
MFCD00871911 | [MOL File]
47491-38-3.mol | [Molecular Weight]
367.87 |
| Chemical Properties | Back Directory | [Melting point ]
90-95°C | [Boiling point ]
544.1±60.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
10.49±0.40(Predicted) | [color ]
Pale Yellow to Light Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
The main phase I metabolites of Azelastine | [Uses]
The main phase I metabolites of Azelastine. | [in vivo]
1.19 Pharmacokinetic parameters of desmethylazelastine after a single oral administration of 1.0 mg/kg azelastine hydrochloride in guinea pigs[1]. | Blood | Lung | | Cmax (ng/mL)[a] | 17.6 | 2863 | | Tmax (h) | 3.0-6.0 | 4.0-6.0 | | Tlag (h) | 0.25 | 0.39 | | AUC0-24 (ng?h/mL)[a] | 180 | 28502 | | t1/2 (h) | 4.24 | 3.90 | | CL (L/h) | 0.213 | | | Lung-blood ratio[b] | 146 | 146 |
[a] For lung, the unit in grams (g) instead of milliliter (mL).
[b] Mean value calculated from all time points.
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