| Identification | Back Directory | [Name]
GALNON | [CAS]
475115-35-6 | [Synonyms]
GALNON
FMoc-Cha-Lys-AMC
Galnon, Fmoc-Cha-Lys-AMC
FMoc-b-cyclohexyl-Ala-Lys-AMC
FMOC-BETA-CYCLOHEXYL-ALA-LYS-AMC
3-CYCLOHEXYL-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-ALANYL-N-(4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-YL)-L-LYSINAMIDE | [Molecular Formula]
C40H46N4O6 | [MDL Number]
MFCD06198924 | [MOL File]
475115-35-6.mol | [Molecular Weight]
678.82 |
| Chemical Properties | Back Directory | [Boiling point ]
937.5±65.0 °C(Predicted) | [density ]
1.242±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: insoluble | [form ]
solid | [pka]
10.68±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Galnon is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon exhibits anticonvulsant and anxiolytic effects[1][2]. | [Biological Activity]
Novel non-peptide galanin GAL 1 receptor agonist (K i = 4.8 μ M). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo ; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice. | [References]
[1] Bartfai T, et, al. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5. DOI:10.1073/pnas.0403802101
[2] Rajarao SJR, et, al. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides. 2007 Oct;41(5):307-20. DOI:10.1016/j.npep.2007.05.001 |
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