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4758-99-0

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4758-99-0 Structure

4758-99-0 Structure
IdentificationBack Directory
[Name]

DIHYDROATISINE HCl
[CAS]

4758-99-0
[Synonyms]

DIHYDROATISINE HCl
Atisinium chloride
[Molecular Formula]

C22H34ClNO2
[MDL Number]

MFCD32263451
[MOL File]

4758-99-0.mol
[Molecular Weight]

379.97
Chemical PropertiesBack Directory
[Melting point ]

311-312 °C (decomp)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
[References]

[1] WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233.
[2] Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62. DOI:10.1016/j.jep.2010.05.057
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