| Identification | Back Directory | [Name]
Bay 41-4109 (less active enantiomer) | [CAS]
476617-51-3 | [Synonyms]
Bay 41-4109 (less active enantiomer)
Bayer 41-4109 less active enantiomer
BAY41-4109 LESS ACTIVE ENANTIOMER; BAY-41-4109 LESS ACTIVE ENANTIOMER; BAYER 41-4109 LESS ACTIVE ENANTIOMER
methyl (4S)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4S)- | [Molecular Formula]
C18H13ClF3N3O2 | [MOL File]
476617-51-3.mol | [Molecular Weight]
395.76 |
| Hazard Information | Back Directory | [Uses]
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. | [in vivo]
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs[1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid[2]. | [storage]
Store at -20°C | [References]
[1] Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. DOI:10.1016/s0166-3542(01)00216-9
[2] Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. DOI:10.1002/jmr.801
[3] Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67. DOI:10.1179/joc.2008.20.4.458 |
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