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477-29-2

477-29-2 Structure

477-29-2 Structure
IdentificationBack Directory
[Name]

COLCHICOSIDE
[CAS]

477-29-2
[Synonyms]

Nsc32992
Nsc624672
Aids012001
Aids-012001
COLCHICOSIDE IMPURITY
Colchicine impurity D
COLCHICOSIDE USP/EP/BP
Thiocolchicoside Impurity D
Thiocolchicoside EP Impurity D
3-Demethylcolchicine glucoside
N-[(7S,12aRa)-3-(beta-D-Glucopyrano
Colchicine EP impurity D (Colchicoside)
Colchicine Impurity 4(Colchicine EP Impurity D)
N-[3-(Hexopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[A]heptalen-7-yl]acetamide
(S)-7-Acetylamino-6,7-dihydro-3-(β-D-glucopyranosyloxy)-1,2,10-trimethoxybenzo[a]heptalen-9(5H)-one
(S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-triMethoxy-9-oxobenzo[a]heptalen-7-yl]acetaMide
N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro- 1,2,10-triMethoxy-9-oxobenzo[a]heptalen-7-yl]acetaMide
Acetamide, N-[(7S)-3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
N-[(7S,12aRa)-3-(β-D-glucopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide (colchicoside)
N-((S)-1,2,10-trimethoxy-9-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
ColchicosideQ: What is Colchicoside Q: What is the CAS Number of Colchicoside Q: What is the storage condition of Colchicoside Q: What are the applications of Colchicoside
[EINECS(EC#)]

207-513-0
[Molecular Formula]

C27H33NO11
[MDL Number]

MFCD01736974
[MOL File]

477-29-2.mol
[Molecular Weight]

547.554
Chemical PropertiesBack Directory
[Melting point ]

194-197°C
[Boiling point ]

620.17°C (rough estimate)
[density ]

1.3430 (rough estimate)
[refractive index ]

1.6400 (estimate)
[storage temp. ]

Refrigerator
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[pka]

12.74±0.70(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Skull and Crossbones (GHS06)
GHS06
[Signal word ]

Danger
[Hazard statements ]

H301
[Precautionary statements ]

P264-P270-P301+P310-P321-P330-P405-P501
[REACH Registrations]

Active
Hazard InformationBack Directory
[Chemical Properties]

Pale Yellow Solid
[Uses]

A significantly toxic Colchicine analog with no anti-inflammatory properties.
[Definition]

ChEBI: Colchicoside is a carbotricyclic compound, an alkaloid and a member of acetamides.
[Purification Methods]

Purify colchicoside by chromatography through alumina and eluting with CHCl3, then recrystallising from Me2CO, m 275-280o (after releasing solvent at 180o). It also crystallises from EtOH; see colchicine. The tetraacetate has m 175-177o, [] D 15 -57o (c 1, CHCl3). [Bellet et al. Ann Pharm Fr 10 241 1952, Chem Abstr 47 3323 1953, Beilstein 14 IV 946 for colchicine.]
Spectrum DetailBack Directory
[Spectrum Detail]

COLCHICOSIDE(477-29-2)1HNMR
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