| Identification | Back Directory | [Name]
N-(7-(1-[4-(TERT-BUTYL)PHENOXY]ETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)-N'-METHOXYIMINOFORMAMIDE | [CAS]
477865-65-9 | [Synonyms]
N-(7-(1-[4-(TERT-BUTYL)PHENOXY]ETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)-N'-METHOXYIMINOFORMAMIDE
(E)-N-{7-[1-(4-tert-butylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-methoxymethanimidamide
Methanimidamide, N'-[7-[1-[4-(1,1-dimethylethyl)phenoxy]ethyl][1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N-methoxy- | [Molecular Formula]
C19H24N6O2 | [MDL Number]
MFCD00243643 | [MOL File]
477865-65-9.mol | [Molecular Weight]
368.43 |
| Hazard Information | Back Directory | [Description]
B-TPMF is the first small-molecule inhibitor with significant selectivity among the KCa2 channel subtypes. | [Uses]
B-TPMF is a selective inhibitor of the KCa2.1 channel, with an IC50 of 30 nM, and it has a competitive functional interaction with CM-TPMF[1]. | [References]
[1] Charlotte Hougaard, et al. Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype. Mol Pharmacol. 2012 Feb;81(2):210-9. DOI:10.1124/mol.111.074252 |
|
| Company Name: |
Key Organics Ltd.
|
| Tel: |
+44 (0) 1840-212137 |
| Website: |
www.keyorganics.net |
|