| Identification | Back Directory | [Name]
EMODICACID | [CAS]
478-45-5 | [Synonyms]
EMODICACID
Emodinic acid
4,5,7-Trihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
9,10-Dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
2-Anthracenecarboxylic acid, 9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo- | [Molecular Formula]
C15H8O7 | [MOL File]
478-45-5.mol | [Molecular Weight]
300.22 |
| Chemical Properties | Back Directory | [Melting point ]
345-350 °C (decomp)(Solv: acetic acid (64-19-7)) | [Boiling point ]
703.8±60.0 °C(Predicted) | [density ]
1.798±0.06 g/cm3(Predicted) | [pka]
3.10±0.20(Predicted) | [LogP]
2.941 (est) |
| Hazard Information | Back Directory | [Uses]
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1]. | [Definition]
ChEBI: Emodicacid is a member of anthracenes. | [References]
[1] Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853. DOI:10.1007/s11418-021-01526-w |
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