| Identification | Back Directory | [Name]
1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)- | [CAS]
478082-99-4 | [Synonyms]
Ro4368554
3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)-1H-indole
7-(4-methyl-1-piperazinyl)-3-(phenylsulfonyl)-1H-Indole
1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)- | [Molecular Formula]
C19H21N3O2S | [MDL Number]
MFCD16875430 | [MOL File]
478082-99-4.mol | [Molecular Weight]
355.45 |
| Chemical Properties | Back Directory | [Melting point ]
160-162 °C | [Boiling point ]
596.8±50.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
15.49±0.30(Predicted) | [color ]
off-white | [InChI]
1S/C19H21N3O2S/c1-21-10-12-22(13-11-21)17-9-5-8-16-18(14-20-19(16)17)25(23,24)15-6-3-2-4-7-15/h2-9,14,20H,10-13H2,1H3 | [InChIKey]
AOPYPEADLGTXRA-UHFFFAOYSA-N | [SMILES]
CN1CCN(CC1)c2cccc3c(c[nH]c23)S(=O)(=O)c4ccccc4 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
2 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
Ro4368554 is a selective 5-Hydroxytryptamine 6 (5-HT6) receptor antagonists. | [Biochem/physiol Actions]
Ro4368554 is a 5-HT6 receptor antagonist. RO4368554 acts selectively at 5-HT6 receptors where it binds with a greater than 100-fold selectivity over other monoamine receptor subtypes (-log M pKi = 9.4 at 5-HT6 and 7.1 at 5-HT2A). | [IC 50]
5-HT6 Receptor |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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