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478913-91-6

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478913-91-6 Structure

478913-91-6 Structure
IdentificationBack Directory
[Name]

L-ProlinaMide, (2R)-2-butyl-N-forMyl-N-hydroxy-β-alanyl-N-(5-fluoro-1-oxido-2-pyridinyl)-
[CAS]

478913-91-6
[Synonyms]

LBM415
NVP-PDF-713
(2R)-2-BUTYL-N-FORMYL-N-HYDROXY--ALANYL-N-(5-FLUORO-1-OXIDO-2-PYRIDINYL)-L-PROLINAMIDE
L-ProlinaMide, (2R)-2-butyl-N-forMyl-N-hydroxy-β-alanyl-N-(5-fluoro-1-oxido-2-pyridinyl)-
[Molecular Formula]

C18H25FN4O5
[MDL Number]

MFCD22741896
[MOL File]

478913-91-6.mol
[Molecular Weight]

396.41
Chemical PropertiesBack Directory
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

8.73±0.69(Predicted)
Hazard InformationBack Directory
[Uses]

LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC90 range of 0.12-8 μg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy[1].
[References]

[1] Fritsche TR, et al. Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance. Antimicrob Agents Chemother. 2005 Apr;49(4):1468-76. DOI:10.1128/AAC.49.4.1468-1476.2005
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