| Identification | Back Directory | [Name]
GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL | [CAS]
479065-85-5 | [Synonyms]
ORN8, UROTENSIN II, HUMAN
GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL
L-Valine, L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (5→10)-disulfide (9CI) | [Molecular Formula]
C63H83N13O18S2 | [MDL Number]
MFCD07366697 | [MOL File]
479065-85-5.mol | [Molecular Weight]
1374.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
solid | [color ]
White lyophilised | [Sequence]
Glu-Thr-Pro-Asp-Cys-Phe-Trp-{Orn}-Tyr-Cys-Val (Disulfide bridge:Cys5-Cys10) |
| Hazard Information | Back Directory | [Description]
Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from
FRAT1, the mammalian version of GSK-3-binding protein. Binds
to GSK-3, inhibiting its interaction with axin, and also blocks
GSK-3-catalyzed phosphorylation of axin and β-catenin. Does
not affect GSK-3-mediated phosphorylation of glycogen
synthase or eIF2B. | [Uses]
[Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293[1]. | [storage]
Desiccate at -20°C | [References]
[1] Camarda V, et al. Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors. Eur J Pharmacol. 2004 Sep 13;498(1-3):83-6. DOI:10.1016/j.ejphar.2004.07.089
[2] Camarda V, et al. A new ligand for the urotensin II receptor. Br J Pharmacol. 2002 Oct;137(3):311-4. DOI:10.1038/sj.bjp.0704895 |
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