| Identification | Back Directory | [Name]
AUDA | [CAS]
479413-70-2 | [Synonyms]
AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
Dodecanoic acid, 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]- | [Molecular Formula]
C23H40N2O3 | [MDL Number]
MFCD12912267 | [MOL File]
479413-70-2.mol | [Molecular Weight]
392.58 |
| Chemical Properties | Back Directory | [Melting point ]
114 °C(Solv: hexane (110-54-3)) | [Boiling point ]
592.7±19.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: ≥10mg/mL at warmed to 60°C | [form ]
powder | [pka]
4.78±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23- | [InChIKey]
XLGSEOAVLVTJDH-UKBVAGSOSA-N | [SMILES]
OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2 |
| Hazard Information | Back Directory | [Uses]
AUDA is an inhibitor of sEH and selective activator of PPARα. | [Biological Activity]
Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.''AUDA is a potent inhibitor of soluble epoxide hydrolase | [in vivo]
AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels[3]. | Animal Model: | Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g)[3] | | Dosage: | 10 mg/kg | | Administration: | i.p.; 14 days | | Result: | Reduced TNF-α, MMP-9 and IL-1β expression levels.
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| [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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