| Identification | Back Directory | [Name]
Amentoflavone 4',4''',7''-trimethyl ether | [CAS]
481-45-8 | [Synonyms]
Kayaflavone
Amentoflavone 4',4''',7''-trimethyl ether
Amentoflavone 4',4''',7''-trimethyl ether USP/EP/BP
2-(4-Methoxyphenyl)-5-hydroxy-7-methoxy-8-[2-methoxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)- | [Molecular Formula]
C33H24O10 | [MDL Number]
MFCD00017448 | [MOL File]
481-45-8.mol | [Molecular Weight]
580.54 |
| Chemical Properties | Back Directory | [Melting point ]
314-315 °C (decomp)(Solv: methanol (67-56-1)) | [Boiling point ]
815.4±65.0 °C(Predicted) | [density ]
1.445±0.06 g/cm3(Predicted) | [pka]
6.00±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC50 value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease[1]. | [Synthesis]
Willow leaf loosestrife leaves crushed, weighing 20kg, with 8 times 90% methanol solution ultrasonic extraction for 30 minutes, extracted three times, the extract was concentrated under reduced pressure and added to the HZ816 macroporous resin column adso | [References]
[1] Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. DOI:10.1016/j.bmcl.2015.04.106
[2] Sun CM, et al. Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod. 1997 Apr;60(4):382-4. DOI:10.1021/np960608e |
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G-CLONE
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