| Identification | Back Directory | [Name]
1-(3-chlorophenyl)biguanide | [CAS]
48144-44-1 | [Synonyms]
Imidodicarbonimidic diamide, N-(3-chlorophenyl)- | [Molecular Formula]
C8H10ClN5 | [MDL Number]
MFCD01170843 | [MOL File]
48144-44-1.mol | [Molecular Weight]
211.65 |
| Hazard Information | Back Directory | [Uses]
m-Chlorophenylbiguanide (mCPBG) is a potent high-affinity agonist of the 5-HT3 receptor, exhibiting an inhibitory effect on long-term potentiation (LTP) in the mossy fiber-CA3 system. mCPBG attenuates the magnitude of LTP at concentrations of 0.3-1 microM, demonstrating its role in modulating synaptic plasticity. Additionally, the impact of mCPBG on LTP is reversible by the GABAA receptor antagonist bicuculline, indicating a connection between its action and GABAergic neurotransmission. | [Definition]
ChEBI:M-Chlorophenylbiguanide is a member of monochlorobenzenes and a member of biguanides. | [References]
[1] Inhibitory influence via 5-HT3 receptors on the induction of LTP in mossy fiber-CA3 system of guinea-pig hippocampal slices DOI:10.1016/0168-0102(94)90163-5 |
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