| Identification | Back Directory | [Name]
Saccharin 1-methylimidazole (SMI) | [CAS]
482333-74-4 | [Synonyms]
Saccharin 1-methylimidazole
Saccharin 1-methylimidazole (SMI) | [Molecular Formula]
C11H11N3O3S | [MDL Number]
MFCD31657257 | [MOL File]
482333-74-4.mol | [Molecular Weight]
265.29 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:52.67(Max Conc. mg/mL);198.54(Max Conc. mM)
Water:53.0(Max Conc. mg/mL);199.78(Max Conc. mM)
Ethanol:31.5(Max Conc. mg/mL);118.74(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);18.85(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.69(Max Conc. mM) | [form ]
A solid | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Description]
Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides. It catalyzes the phosphoramidite coupling reaction of the 5'' hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion. | [Uses]
Saccharin 1-Methylimidazole is a reagent used for nucleic acid synthesis (1,2). | [References]
[1] RUSSELL M A, LAWS A P, ATHERTON J H, et al. The mechanism of the phosphoramidite synthesis of polynucleotides?[J]. Organic & Biomolecular Chemistry, 2008, 18: 3270-3275. DOI: 10.1039/b808999j
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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