| Identification | Back Directory | [Name]
Flavipin | [CAS]
483-53-4 | [Synonyms]
3,4,5-Trihydroxy-6-methyl-1,2-benzenedicarbaldehyde
1,2-Benzenedicarboxaldehyde, 3,4,5-trihydroxy-6-methyl- | [Molecular Formula]
C9H8O5 | [MOL File]
483-53-4.mol | [Molecular Weight]
196.16 |
| Chemical Properties | Back Directory | [Melting point ]
233-234 °C (decomp) | [Boiling point ]
353.7±42.0 °C(Predicted) | [density ]
1.577±0.06 g/cm3(Predicted) | [pka]
6.86±0.33(Predicted) |
| Hazard Information | Back Directory | [Uses]
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2]. | [References]
[1] "Alzahrani A, et al. Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis. Saudi Pharm J. 2020;28(12):1605-1615.
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[2] Li H, et al. Polyketides from two Chaetomium species and their biological functions. J Antibiot (Tokyo). 2018;71(7):677-681. DOI:10.1038/s41429-018-0047-x |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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