| Identification | Back Directory | [Name]
1,2-Cyclopentanediol, 3-amino-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)- | [CAS]
483341-15-7 | [Synonyms]
A286501 A-286501 A 286501 1,2-Cyclopentanediol, 3-amino-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)- | [Molecular Formula]
C11H14BrN5O2 | [MOL File]
483341-15-7.mol | [Molecular Weight]
328.17 |
| Hazard Information | Back Directory | [Uses]
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents[1]. | [References]
[1] Jarvis MF, et al. Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor. Pain. 2002 Mar;96(1-2):107-18. DOI:10.1016/s0304-3959(01)00435-3 |
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