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483341-15-7

483341-15-7 Structure

483341-15-7 Structure
IdentificationBack Directory
[Name]

1,2-Cyclopentanediol, 3-amino-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)-
[CAS]

483341-15-7
[Synonyms]

A286501
A-286501
A 286501
1,2-Cyclopentanediol, 3-amino-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)-
[Molecular Formula]

C11H14BrN5O2
[MOL File]

483341-15-7.mol
[Molecular Weight]

328.17
Chemical PropertiesBack Directory
[Boiling point ]

450.4±45.0 °C(Predicted)
[density ]

2.26±0.1 g/cm3(Predicted)
[pka]

13.04±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents[1].
[References]

[1] Jarvis MF, et al. Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor. Pain. 2002 Mar;96(1-2):107-18. DOI:10.1016/s0304-3959(01)00435-3
483341-15-7 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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