| Identification | Back Directory | [Name]
neoagarobiose | [CAS]
484-58-2 | [Synonyms]
neoagarobiose
Neoagarobiose Mixed anomers
O-3,6-Anhydro-alpha-L-galactopyranosyl(1-3)-D-galactose | [Molecular Formula]
C12H20O10 | [MDL Number]
MFCD00133656 | [MOL File]
484-58-2.mol | [Molecular Weight]
324.28 |
| Chemical Properties | Back Directory | [Melting point ]
207-208 °C | [Boiling point ]
731.3±60.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.25±0.20(Predicted) |
| Questions and Answers (Q&A) | Back Directory | [Description]
Many kinds of skin moisturizers classifiable as polyhydric alcohols containing glycerol and propyrenglycol, natural moisturizing factor (NMF)2) and polysaccharides such as hyaluronic acid3 ) have been developed in the dermatological field.
Neoagarobiose, a disaccharide, showed a higher hygroscopic ability than glycerol or hyaluronic acid, typical moisturizing reagents. Beside, neoagarobiose whitened B16 murine melanoma cells, and showed low cytotoxicity. Therefore neoagarobiose was a rare reagent showing both moisturizing and whitening effects.
Commonly added to food and personal care products as a thickening agent, agar is a seaweed-derived product comprised of numerous agarose polymers. Neoagarobiose is the base unit of agarose that functions as a moisturizer for skin care as well as having mild skin lightening properties. Unfortunately, it is not commercially available due to the difficulties in breaking agar and agarose down into neoagarobiose.
Innovative Technology
Researchers at the University of Maryland have identified the genes used to encode marine bacterial enzymes that effectively degrade agar into neoagarobiose. The researchers have cloned the genes into a common vector with a C-terminal His tag for easy purification. The simple production of these enzymes allows for the simple conversion of agar into neoagarobiose allowing for its use in consumer products for the first time.
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| Hazard Information | Back Directory | [Uses]
Neoagarobiose has both a moisturizing effect on skin and a whitening effect on melanoma cells. RagaA11 is an endo-type beta-agarase hydrolysing not only agarose, but also neoagarotetraose, to yield neoagarobiose as the final main product[1]. | [References]
[1] Ohta Y, et al. High-level expression of a neoagarobiose-producing beta-agarase gene from Agarivorans sp. JAMB-A11 in Bacillus subtilis and enzymic properties of the recombinant enzyme. Biotechnol Appl Biochem. 2005 Apr;41(Pt 2):183-91. DOI:10.1042/BA20040083 |
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| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
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| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
G-CLONE
|
| Telephone: |
400-910-1997 15330005590 |
| Website: |
http://www.g-clone.com/ |
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