| Identification | Back Directory | [Name]
5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione | [CAS]
484049-04-9 | [Synonyms]
104868
DPH >=98% (HPLC)
5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin
5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione
5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione
2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]- | [Molecular Formula]
C18H13FN4O2 | [MDL Number]
MFCD03268950 | [MOL File]
484049-04-9.mol | [Molecular Weight]
336.32 |
| Chemical Properties | Back Directory | [density ]
1.45 | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [pka]
8.36±0.10(Predicted) | [color ]
white to tan | [InChI]
1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25) | [InChIKey]
MPQWYPLPWGUMJE-UHFFFAOYSA-N | [SMILES]
Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4 |
| Hazard Information | Back Directory | [Uses]
DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies. | [Biochem/physiol Actions]
DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk. |
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