| Identification | Back Directory | [Name]
CORTISTATIN-8 | [CAS]
485803-62-1 | [Synonyms]
CORTISTATIN-8
PCFwKTCK(Disulfide bridge 2 - 7)
L-Lysinamide, L-prolyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide | [Molecular Formula]
C47H68N12O9S2 | [MDL Number]
MFCD11045146 | [MOL File]
485803-62-1.mol | [Molecular Weight]
1009.25 |
| Chemical Properties | Back Directory | [Boiling point ]
1451.7±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
≥ 100.9mg/mL in DMSO | [form ]
Solid | [pka]
12.56±0.70(Predicted) | [color ]
White to off-white | [Sequence]
Pro-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Lys-NH2 (disulfide bridge: Cys2-Cys7) |
| Hazard Information | Back Directory | [Uses]
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. | [IC 50]
GHSR1a | [References]
[1] F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42(1):89-93. DOI:10.1016/j.npep.2007.09.006 |
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