| Identification | Back Directory | [Name]
Syringaresinol | [CAS]
487-35-4 | [Synonyms]
4,4'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenol]
Phenol,4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxy- | [Molecular Formula]
C22H26O8 | [MDL Number]
MFCD09954361 | [MOL File]
487-35-4.mol | [Molecular Weight]
418.44 |
| Chemical Properties | Back Directory | [Melting point ]
170-172 °C | [Boiling point ]
594.7±50.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.55±0.40(Predicted) | [color ]
White to off-white | [Cosmetics Ingredients Functions]
ANTIOXIDANT
SKIN CONDITIONING
SKIN PROTECTING
BLEACHING |
| Hazard Information | Back Directory | [Uses]
Syringaresinol is a lignan that can be extracted from the dragon's blood of the Dracaena tree. Syringaresinol increases NO production by increasing the phosphorylation and dimerization of endothelial NO synthase, exerting a vasodilatory effect. Syringaresinol also inhibits the NF-κB pathway, exerting anti-inflammatory activity and inhibiting arthritis[1][2][3]. | [Definition]
ChEBI: Syringaresinol is a lignan that is 7,9':7',9-diepoxylignane substituted by hydroxy groups at positions 4 and 4' and methoxy groups at positions 3, 3', 5 and 5' respectively. It has a role as a plant metabolite. It is a lignan, a polyphenol, an aromatic ether, a furofuran and a polyether. | [References]
[1] Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982. DOI:10.1016/j.intimp.2023.109982
[2] YingLUO, et al. Chemical Constituents from Dragon's Blood of Dracaena cambodiana. Chinese Journal of Natural Medicines, Volume 9, Issue 2, March 2011, Pages 112-114.
[3] Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201. DOI:10.3858/emm.2012.44.3.014 |
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