| Identification | Back Directory | [Name]
N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride | [CAS]
487051-12-7 | [Synonyms]
SNAP-94847
SNAP-94847 >=98% (HPLC)
SNAP 94847 hydrochloride
N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide
Propanamide, N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-
N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride | [Molecular Formula]
C29H32F2N2O2 | [MOL File]
487051-12-7.mol | [Molecular Weight]
478.57 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChIKey]
DEDUDFNRQKUBRH-UHFFFAOYSA-N | [SMILES]
Fc1c(ccc(c1)Oc2ccc(cc2)CN3CCC(CC3)c4c(ccc(c4)NC(=O)C(C)C)C)F.Cl |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS09 | [Signal word ]
Warning | [Hazard statements ]
H410 | [Precautionary statements ]
P273-P501 | [Hazard Codes ]
N | [Risk Statements ]
50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
SNAP 94847 Hydrochloride is an MCH1 antagonist. | [Biological Activity]
SNAP-94847 is a potent antagonist of the melanin-concentrating hormone receptor MCHR-1. SNAP-94847 displays anxiolytic and antidepressant activityand reduces food intake in mice. | [in vivo]
SNAP 94847 (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals[2].
SNAP 94847 (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min[2].
SNAP 94847 (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study[3]. | Animal Model: | Rat[2] | | Dosage: | 20?mg/kg | | Administration: | Oral administration; 20?mg/kg; 14 days | | Result: | Exhibited a exaggerated locomotor response to acute quinpirole. |
| Animal Model: | Rat (PK study)[3] | | Dosage: | 10 mg/kg | | Administration: | oral gavage; 10 mg/kg | | Result: | Exhibited good physicochemical properties in rats. |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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