| Identification | Back Directory | [Name]
ST-193 | [CAS]
489416-12-8 | [Synonyms]
ST-193
ST-193 hydrochlorid
ST193 HYDROCHLORIDE; ST 193 HYDROCHLORIDE
1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]- | [Molecular Formula]
C24H25N3O | [MOL File]
489416-12-8.mol | [Molecular Weight]
371.47 |
| Chemical Properties | Back Directory | [Boiling point ]
562.5±60.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 150 mg/mL (403.80 mM) | [form ]
Solid | [pka]
5.20±0.10(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively. | [in vivo]
ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups[3]. | [storage]
Store at -20°C | [References]
[1] Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. DOI:10.1016/j.bmcl.2012.11.093
[2] Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75. DOI:10.1128/JVI.00941-08
[3] Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. DOI:10.1016/j.antiviral.2011.02.012 |
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BOC Sciences
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https://www.bocsci.com |
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