| Identification | Back Directory | [Name]
N'-(2-hydroxybenzylidene)-2,8-dimethyl-3-quinolinecarbohydrazide | [CAS]
491586-42-6 | [Synonyms]
N'-(2-hydroxybenzylidene)-2,8-dimethyl-3-quinolinecarbohydrazide | [Molecular Formula]
C19H17N3O2 | [MOL File]
491586-42-6.mol | [Molecular Weight]
319.357 |
| Hazard Information | Back Directory | [Uses]
AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity [1]. | [References]
[1] Zhang S, et al. Identification of novel GSPT1 degraders by virtual screening and bioassay. Eur J Med Chem. 2024 Jul 5;273:116524. DOI:10.1016/j.ejmech.2024.116524 |
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