| Identification | Back Directory | [Name]
[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonooxypropyl] dihydrogen phosphate | [CAS]
491611-43-9 | [Synonyms]
MRS2298, CID:10432920
[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonooxypropyl] dihydrogen phosphate | [Molecular Formula]
C10H16ClN5O8P2 | [MOL File]
491611-43-9.mol | [Molecular Weight]
431.66 |
| Hazard Information | Back Directory | [Description]
MRS2298 is a potent antagonists of the P2Y 1 receptor, which has antiaggregatory activity in human platelets. | [Uses]
MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca2+ rise in platelets with an IC50 of 810 nM[1]. | [References]
[1] Marco Cattaneo, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002. DOI:10.1016/j.bcp.2004.06.026 |
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