| Identification | Back Directory | [Name]
Urea, N'-[4-[[4-[hydroxybis[4-(trifluoromethyl)phenyl]methyl]-1-piperidinyl]methyl]phenyl]-N,N-dimethyl- | [CAS]
494786-13-9 | [Synonyms]
DCG066
Urea, N'-[4-[[4-[hydroxybis[4-(trifluoromethyl)phenyl]methyl]-1-piperidinyl]methyl]phenyl]-N,N-dimethyl- | [Molecular Formula]
C30H31F6N3O2 | [MOL File]
494786-13-9.mol | [Molecular Weight]
579.58 |
| Chemical Properties | Back Directory | [Boiling point ]
650.5±55.0 °C(Predicted) | [density ]
1.318±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.42±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DCG066 is a G9a inhibitor. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. It displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562. | [Uses]
DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562[1]. | [IC 50]
G9a | [References]
[1] Kondengaden SM, et al. Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines. Eur J Med Chem. 2016 Oct 21;122:382-393. DOI:10.1016/j.ejmech.2016.06.028 |
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