| Identification | Back Directory | [Name]
Caprospinol | [CAS]
4952-56-1 | [Synonyms]
SP233
SP-233
SP 233
Caprospinol
Caprospinol - SP 233
Spirost-5-en-3-ol, 3-hexanoate, (3β,25R)-
(2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl hexa\nnoate | [Molecular Formula]
C33H52O4 | [MDL Number]
MFCD11501551 | [MOL File]
4952-56-1.mol | [Molecular Weight]
512.76 |
| Hazard Information | Back Directory | [Uses]
Caprospinol (SP-233) is a steroid compound candidate based on the structure of 22R-hydroxycholesterol. It has multiple mechanisms of neuroprotection, including binding to β-amyloid protein (Aβ(42)), interacting with the mitochondrial respiratory chain, clearing Aβ(42) monomers, and acting as a σ-1 receptor ligand. It can cross the blood-brain barrier in vivo and restore cognitive impairment, and has the potential to inhibit Alzheimer's disease. | [References]
[1] Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties
[2] Caprospinol: moving from a neuroactive steroid to a neurotropic drug |
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