| Identification | Back Directory | [Name]
N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-trimethoxybenzamide | [CAS]
496793-78-3 | [Synonyms]
N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-trimethoxybenzamide | [Molecular Formula]
C23H20ClN3O4 | [MOL File]
496793-78-3.mol | [Molecular Weight]
437.88 |
| Hazard Information | Back Directory | [Description]
SANT-2 is a potent inhibitor of Shh signaling pathway. | [Uses]
Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC50 value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer[1]. | [References]
[1] Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. DOI:10.1016/j.bmc.2009.06.008 |
|
|