| Chemical Properties | Back Directory | [Boiling point ]
631.4±48.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/mL; Ethanol: 10 mg/mL; Ethanol:PBS (pH 7.2) (1:6): 0.14 mg/mL | [form ]
A crystalline solid | [pka]
12.24±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
OH-C-Chol is a cationic cholesterol derivative. OH-C-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. | [Uses]
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect[1]. | [References]
[1] Hattori Y, et al. siRNA delivery into tumor cells by cationic cholesterol derivative-based nanoparticles and liposomes. Biol Pharm Bull. 2015;38(1):30-8. DOI:10.1248/bpb.b14-00526 |
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