| Identification | Back Directory | [Name]
D77 | [CAS]
497836-10-9 | [Synonyms]
D77
CS-2058
Benzoic acid, 4-[[5-bromo-4-[[2,4-dioxo-3-(2-oxo-2-phenylethyl)-5-thiazolidinylidene]methyl]-2-ethoxyphenoxy]methyl]- | [Molecular Formula]
C28H22BrNO7S | [MDL Number]
MFCD03082603 | [MOL File]
497836-10-9.mol | [Molecular Weight]
596.45 |
| Chemical Properties | Back Directory | [Boiling point ]
762.9±70.0 °C(Predicted) | [density ]
1.525±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.14±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).
IC50 value: 23.8 μg/ml (EC50, in MT-4 cell ), 5.03 μg/ml (EC50, in C8166 cell)
Target: HIV-1
in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of α-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD. | [References]
[1] Du L, et al. D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-144. DOI:10.1016/j.bbrc.2008.07.139 |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|