49844-93-1

3934-20-1

5188-07-8

49844-93-1

At -10 °C, 2,4-dichloropyrimidine (20.0 g, 0.13 mol) was dissolved in 150 mL of anhydrous tetrahydrofuran, and sodium methanethiol (49.30 mL, 0.15 mol) was added slowly. The reaction mixture was gradually warmed up to room temperature with continuous stirring for 5 h, during which the reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS) or thin-layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed twice with saturated saline (x2). The organic layers were combined, dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The resulting solid was recrystallized with ether and collected by filtration to afford the target product 2-chloro-4-methylthiopyrimidine (Intermediate 10) as a white solid (11.2 g, 52% yield).