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500214-53-9

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500214-53-9 Structure

500214-53-9 Structure
IdentificationBack Directory
[Name]

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-
[CAS]

500214-53-9
[Synonyms]

ARC-111
Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-
[Molecular Formula]

C23H23N3O5
[MDL Number]

MFCD08056235
[MOL File]

500214-53-9.mol
[Molecular Weight]

421.45
Chemical PropertiesBack Directory
[Melting point ]

229-232 °C
[Boiling point ]

648.8±55.0 °C(Predicted)
[density ]

1.325±0.06 g/cm3(Predicted)
[pka]

8.86±0.28(Predicted)
Hazard InformationBack Directory
[Uses]

Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells[1].
[IC 50]

Topoisomerase I
[References]

[1] Li TK, et al. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. Cancer Res. 2003 Dec 1;63(23):8400-7. PMID:14679002
Spectrum DetailBack Directory
[Spectrum Detail]

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-(500214-53-9)1HNMR
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