| Identification | Back Directory | [Name]
2-amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide | [CAS]
500271-63-6 | [Synonyms]
2-APQC
2-amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
1H-Pyrrolo[2,3-b]quinoxaline-3-carboxamide, 2-amino-1-[(4-fluorophenyl)methyl]-N-pentyl- | [Molecular Formula]
C23H24FN5O | [MOL File]
500271-63-6.mol | [Molecular Weight]
405.47 |
| Chemical Properties | Back Directory | [Boiling point ]
679.9±55.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.26±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
2-APQC is a SIRT3 activator with the Kd value of 2.756?μM. 2-APQC improves heart failure in vitro and in vivo[1]. | [References]
[1] Peng F, et al. 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal Transduct Target Ther. 2024;9(1):133. DOI:10.1038/s41392-024-01816-1 |
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