| Identification | Back Directory | [Name]
5H-Indeno[1,2-c]isoquinoline-9-sulfonaMide, 6,11-dihydro-N-[3-(4-Morpholinyl)propyl]-5-oxo- | [CAS]
501364-82-5 | [Synonyms]
IN01001
N-(3-morpholin-4-ylpropyl)-5-oxo-6,11-dihydroindeno[1,2-c]isoquinoline-9-sulfonamide
5H-Indeno[1,2-c]isoquinoline-9-sulfonaMide, 6,11-dihydro-N-[3-(4-Morpholinyl)propyl]-5-oxo- | [Molecular Formula]
C23H25N3O4S | [MDL Number]
MFCD19443171 | [MOL File]
501364-82-5.mol | [Molecular Weight]
439.53 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 31.25 mg/mL (71.10 mM) | [form ]
Solid | [pka]
11.60±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2]. | [IC 50]
PARP | [References]
[1] Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60. DOI:10.1016/j.canlet.2003.10.029
[2] Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13. DOI:10.1007/s10637-007-9072-5 |
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