| Identification | Back Directory | [Name]
DC1-SMe | [CAS]
501666-85-9 | [Synonyms]
DC1-SMe
1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]- | [Molecular Formula]
C35H30ClN5O4S2 | [MDL Number]
MFCD31746905 | [MOL File]
501666-85-9.mol | [Molecular Weight]
684.23 |
| Chemical Properties | Back Directory | [Boiling point ]
961.4±65.0 °C(Predicted) | [density ]
1.522±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.47±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer. | [IC 50]
Duocarmycins | [References]
[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m |
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