| Identification | Back Directory | [Name]
GW768505A | [CAS]
501693-25-0 | [Synonyms]
GW768505A
GW768505A free base
Urea,N-[4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]- | [Molecular Formula]
C27H19F4N5O3 | [MDL Number]
MFCD29770798 | [MOL File]
501693-25-0.mol | [Molecular Weight]
537.47 |
| Hazard Information | Back Directory | [Description]
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 that has anti-angiogenic activity. | [Uses]
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]. | [IC 50]
KDR; Tie2; Tie-2 | [References]
[1] Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. DOI:10.1016/j.bmcl.2006.12.077
[2] Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103. DOI:10.1038/nbt.3374 |
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