| Identification | Back Directory | [Name]
Mezilamine | [CAS]
50335-55-2 | [Synonyms]
Mezilamine
4-Chloro-2-methylamino-5-methylthio-6-(4-methyl-1-piperazinyl)pyrimidine
N-Methyl-4-chloro-5-(methylthio)-6-(4-methylpiperazino)pyrimidine-2-amine
4-Chloro-N-methyl-6-(4-methylpiperazin-1-yl)-5-(methylthio)pyrimidin-2-amine
2-Pyrimidinamine, 4-chloro-N-methyl-6-(4-methyl-1-piperazinyl)-5-(methylthio)- | [Molecular Formula]
C11H18ClN5S | [MDL Number]
MFCD00868718 | [MOL File]
50335-55-2.mol | [Molecular Weight]
287.81 |
| Hazard Information | Back Directory | [Uses]
Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of 3H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist[1]. | [References]
[1] G Le Fur, et al. Mezilamine, a new dopamine antagonist, blocks presynaptic but stimulates postsynaptic alpha-adrenoceptors. Eur J Pharmacol. 1979 Oct 15;58(4):359-67. DOI:10.1016/0014-2999(79)90306-6 |
|
|