503555-55-3

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503555-55-3 Structure

Identification	Back Directory
[Name] PHA 408
[CAS] 503555-55-3
[Synonyms] PHA 408 PHA-408 >=98% (HPLC) 8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide 1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
[Molecular Formula] C29H27ClFN7O2
[MDL Number] MFCD17166977
[MOL File] 503555-55-3.mol
[Molecular Weight] 560.02

Chemical Properties	Back Directory
[Boiling point ] 727.4±60.0 °C(Predicted)
[density ] 1.48±0.1 g/cm3(Predicted)
[storage temp. ] -20°C
[solubility ] DMSO: 5mg/mL, clear (warmed)
[form ] powder
[pka] 10.18±0.20(Predicted)
[color ] white to beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319-H335
[Precautionary statements ] P305+P351+P338

Hazard Information	Back Directory
[Uses] PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].
[Biological Activity] PHA-408 is a potentselective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight bindingATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular eventsand to reduce inflammation in animal models of arthritis.
[IC 50] IKK-2
[storage] Store at -20°C
[References] [1] Rajendrasozhan S, et al. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. DOI:10.1016/j.pupt.2010.01.002

503555-55-3 suppliers list

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