| Identification | Back Directory | [Name]
4-CHLORO-1-METHYL-1H-IMIDAZO[4,5-C]PYRIDINE | [CAS]
50432-68-3 | [Synonyms]
4-Chloro-1-methyl-imidazo[4,5-c]pyridine
4-CHLORO-1-METHYL-1H-IMIDAZO[4,5-C]PYRIDINE
1H-Imidazo[4,5-c]pyridine, 4-chloro-1-methyl- | [Molecular Formula]
C7H6ClN3 | [MDL Number]
MFCD00222101 | [MOL File]
50432-68-3.mol | [Molecular Weight]
167.6 |
| Chemical Properties | Back Directory | [Melting point ]
168-170 °C(Solv: cyclohexane (110-82-7); ethyl acetate (141-78-6)) | [Boiling point ]
331.8±45.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
3.13±0.30(Predicted) | [Appearance]
Light brown to black Solid |
| Hazard Information | Back Directory | [Synthesis]
NaH (78 mg, 1.95 mmol, 60% w/w oil solution) was slowly added to a solution of 4-chloro-3H-imidazo[4,5-c]pyridine (100 mg, 0.65 mmol) in DMF (3 mL) at 0 °C under nitrogen protection. The reaction mixture was stirred at 0 °C for 40 min. Subsequently, iodomethane (277 mg, 1.95 mmol) was added at the same temperature. The reaction mixture was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by preparative HPLC to afford 4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine (58, 40.3 mg) and 4-chloro-3-methyl-3H-imidazo[4,5-c]pyridine (59, 41.0 mg), both yellow oils, respectively.LRMS (m/z): [M+H]+ calculated values 168.2, 170.2; measured values 168.0, 170.2. | [References]
[1] Patent: WO2016/101119, 2016, A1. Location in patent: Page/Page column 99; 100 |
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