| Identification | Back Directory | [Name]
Isojacareubin | [CAS]
50597-93-8 | [Synonyms]
Isojacareubin
3H,7H-Pyrano[2,3-c]xanthen-7-one, 6,10,11-trihydroxy-3,3-dimethyl- | [Molecular Formula]
C18H14O6 | [MDL Number]
MFCD02183417 | [MOL File]
50597-93-8.mol | [Molecular Weight]
326.3 |
| Hazard Information | Back Directory | [Uses]
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3]. | [References]
[1] Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585.
[2] Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95(2):e28542. DOI:10.1002/jmv.28542
[3] Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889. DOI:10.1038/srep12889 |
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| Company Name: |
BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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http://www.biobiopha.com |
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