| Identification | Back Directory | [Name]
2-Benzofurancarboxamide, N-phenyl- | [CAS]
50635-12-6 | [Synonyms]
Aβ42 agonist-1
2-Benzofurancarboxamide, N-phenyl- | [Molecular Formula]
C15H11NO2 | [MOL File]
50635-12-6.mol | [Molecular Weight]
237.25 |
| Chemical Properties | Back Directory | [Melting point ]
158 °C(Solv: ethanol, 40% (64-17-5)) | [Boiling point ]
307.3±15.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.90±0.70(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1]. | [References]
[1] Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16. DOI:10.1021/acschemneuro.3c00576 |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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