| Identification | Back Directory | [Name]
Methyl 2-amino-5-bromonicotinate | [CAS]
50735-34-7 | [Synonyms]
2-AMINO-5-BROMONICOTINATE
METHYL 2-AMINO-5-BROMONICOTINAT
METHYL 2-AMINO-5-BROMONICOTINATE
2-AMino-5-broMo-nicotinic acid ethyl ester
2-AMINO-5-BROMO-NICOTINIC ACID METHYL ESTER
METHYL 2-AMINO-5-BROMOPYRIDINE-3-CARBOXYLATE
Methyl 2-amino-5-bromonicotinate ISO 9001：2015 REACH
3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, Methyl e
TIANFU-CHEM Methyl 2-amino-5-bromonicotinate 50735-34-7
3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, Methyl ester
Methyl 2-amino-5-bromopyridine-3-carboxylate, 2-Amino-5-bromo-3-(methoxycarbonyl)pyridine | [EINECS(EC#)]
229-486-4 | [Molecular Formula]
C7H7BrN2O2 | [MDL Number]
MFCD04117787 | [MOL File]
50735-34-7.mol | [Molecular Weight]
231.05 |
| Chemical Properties | Back Directory | [Melting point ]
143-146°C | [Boiling point ]
275.2±35.0 °C(Predicted) | [density ]
1.662±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.45±0.49(Predicted) | [Appearance]
White to yellow Solid | [InChI]
InChI=1S/C7H7BrN2O2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3,(H2,9,10) | [InChIKey]
POWKBBOOIZBIRZ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(Br)C=C1C(OC)=O |
| Hazard Information | Back Directory | [Uses]
Methyl 2-Amino-5-bromonicotinate is a chemical reagent used in the synthesis of pharmaceutical agents. | [Synthesis]
To a stirred solution of methyl 2-aminopyridine-3-carboxylate (2 g, 13.15 mmol) and sodium bicarbonate (2.2 g, 26.31 mmol) in dichloromethane (30 mL) was slowly added a dichloromethane solution of bromine dropwise (1.01 mL bromine dissolved in 20 mL dichloromethane). The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with sodium bisulfite solution (50 mL). The reaction mixture was extracted with dichloromethane (2 x 40 mL) and the combined organic phases were washed with brine (40 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give methyl 2-amino-5-bromopyridine-3-carboxylate as a yellow solid (3 g, 99% yield).LCMS m/z (79Br/81Br) 231/233 (M+H)+. | [References]
[1] Patent: US2017/29420, 2017, A1. Location in patent: Paragraph 0034 |
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