| Identification | Back Directory | [Name]
Benzamide, N-[cis-4-[[4-(dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluoro- | [CAS]
509118-03-0 | [Synonyms]
Benzamide, N-[cis-4-[[4-(dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluoro- | [Molecular Formula]
C23H25F2N5O | [MOL File]
509118-03-0.mol | [Molecular Weight]
425.47 |
| Hazard Information | Back Directory | [Uses]
ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity[1]. | [References]
[1] Kanuma K, et al. Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. DOI:10.1016/j.bmcl.2005.05.121 |
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