| Identification | Back Directory | [Name]
2,4-Quinazolinediamine, N2-[cis-4-[[2-[4-bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl- | [CAS]
509145-82-8 | [Synonyms]
ATC0065 HCl
2,4-Quinazolinediamine, N2-[cis-4-[[2-[4-bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl- | [Molecular Formula]
C25H29BrF3N5O | [MOL File]
509145-82-8.mol | [Molecular Weight]
552.43 |
| Hazard Information | Back Directory | [Uses]
ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities[1]. | [References]
[1] Shigeyuki Chaki, et al. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9. DOI:10.1124/jpet.104.081711 |
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