| Identification | Back Directory | [Name]
saikogenin A | [CAS]
5092-09-1 | [Synonyms]
Clinopodiside A1
Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)- | [Molecular Formula]
C30H48O4 | [MDL Number]
MFCD00238674 | [MOL File]
5092-09-1.mol | [Molecular Weight]
472.7 |
| Chemical Properties | Back Directory | [Melting point ]
287-293 °C | [Boiling point ]
607.4±55.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.47±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor. | [Biochem/physiol Actions]
Saikogenin A is a naturally occurring plant extract that has been shown to have a variety of biological activities. saikogenin A has anti-inflammatory and tumour cell growth inhibiting effects. Its anti-inflammatory effect is due to an increase in corticosterone caused by the release of ACTH and has a direct effect on the inflammatory process. It also inhibits the absorption of ultraviolet light by human skin cells and erythromycin-induced UvB damage. | [in vitro]
Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide. | [in vivo]
Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation. | [target]
| [storage]
Store at -20°C |
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