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51014-29-0

51014-29-0 Structure

51014-29-0 Structure
IdentificationBack Directory
[Name]

Isocorynoxeine
[CAS]

51014-29-0
[Synonyms]

Isocorynoxeine
Isocorynoxeine, BR
Isocorynoxeine USP/EP/BP
Isocorynoxeine (7-Isocorynoxeine)
(16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-
(alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
[Molecular Formula]

C22H26N2O4
[MDL Number]

MFCD20527292
[MOL File]

51014-29-0.mol
[Molecular Weight]

382.46
Chemical PropertiesBack Directory
[Boiling point ]

562.7±50.0 °C(Predicted)
[density ]

1.25
[solubility ]

DMSO : 50 mg/mL (130.74 mM; Need ultrasonic)
[form ]

Powder
[pka]

13.54±0.60(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

The leaves of Mitragyna rotundlfolia grown in Burma have recently been found to contain this alkaloid. This is the first reported occurrence of the base in nature. The structure has been established from spectroscopic investigations.
[Uses]

7-Isocorynoxeine is a bioactive oxindole alkaloid in the Uncaria species. Displays wide array of beneficial cardiovascular and cardiocerebral vascular system effects.
[in vivo]

The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01][1].

[target]

5-HT2A receptor | NO
[IC 50]

5-HT2A Receptor: 72.4 μM (IC50)
[References]

Houghton, Shellard, Planta Med., 26, 104 (1974)
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