| Identification | Back Directory | [Name]
AMCINONIDE | [CAS]
51022-69-6 | [Synonyms]
Amicla
Visderm
cl-34699
Amciderm
Amcinonid
Penticort
cyclocort
Amcinopol
AMCINONIDE
Amcinonide (200 mg)
Amcinonide Solution, 100ppm
(11-beta,16-alpha)-fluoro-11-hydroxy
Amcinonide (200 mg)H0D3460.995mg/mg(ai)
20-dione,21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-pregna-4-diene-3
(11β,16α)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione
Spiro[cyclopentane-1,8'-[2H]naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole], pregna-1,4-diene-3,20-dione deriv.
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-, (11β,16α)-
(11alpha,16alpha)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione
2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-2',4',6a',6b',7',8',8a',8b',11a',12',12a',12b'-dodecahydro-1'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate | [EINECS(EC#)]
256-915-2 | [Molecular Formula]
C28H35FO7 | [MDL Number]
MFCD00213379 | [MOL File]
51022-69-6.mol | [Molecular Weight]
502.57 |
| Chemical Properties | Back Directory | [Melting point ]
>216°C (dec.) | [Boiling point ]
635.9°C (rough estimate) | [density ]
1.33±0.1 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.5860 (estimate) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetonitrile (Slightly), Dichlomethane (Slightly), Dioxane (Slightly), Methanol | [form ]
neat | [pka]
13.09±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Cyclocort,Lederle,US,1979 | [Uses]
antiinflammatory | [Uses]
Glucocorticoid. | [Definition]
ChEBI: Amcinonide is a corticosteroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 20-oxo steroid, an acetate ester, a spiroketal and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane. | [Manufacturing Process]
An 11.1 g (24.1 mmol) portion of the compound 16α,17α-
cyclopentylidenedioxy-9α-fluoro-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione
is placed in a 250 ml round-bottom flask. A 100 ml portion of pyridine is
added and the mixture is stirred to a complete solution. A 5.5 ml (54.6 mmol)
portion of acetic anhydride is added dropwise and the mixture is stirred for
2% hours. An 11 ml portion of methanol is added and the mixture is stirred
an additional hour. This mixture is concentrated under reduced pressure to
about 10 to 15 ml and then poured slowly into a mixture of ice, water and
dilute hydrochloric acid. This mixture is stirred and the solid which forms is
collected by filtration, washed with water to a neutral pH and air dried yielding
11.5 g. This solid is taken up in hot acetone, treated with activated charcoal
and filtered while hot through diatomaceous earth. The filtrate is concentrated
on a steam bath while adding n-hexane to the point of incipient crystallization.
This mixture is allowed to cool to room temperature. The solid which forms is collected by filtration, washed with acetone-n-hexane (1:14) and air dried
yielding 7.0 g of the desired product. | [Brand name]
Cyclocort (Astellas. | [Therapeutic Function]
Topical corticosteroid, Antiinflammatory | [General Description]
Amcinonide, 21-(acetyloxy)-16α,17-[cyclopentylidenebis(oxy)]-9-fluoro-11β-hydroxypregna-1,4-diene-3,20-dione (Cyclocort). |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878 |
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https://www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
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