| Identification | Back Directory | [Name]
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE | [CAS]
5122-36-1 | [Synonyms]
FAPy-adenine
DIAMINO-15N2)
DIAMINO-15N2, 98%)
FAPYADENINE(FORMYL-13C
4,6-diamino-5-n-formamidopyrimidine
4,6-DIAMONO-5-(FORMYLAMINO)PYRIMIDNE
N-(4,6-Diaminopyrimidin-5-yl)formamide
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
Formamide, N-(4,6-diamino-5-pyrimidinyl)-
4,6-Diamino-5-(Formylamino)-Pyrimidine HCl
4,6-Diaminobenzene-5-formamidopyrimide-formyl-13C, diamino-15N2 | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C5H7N5O | [MDL Number]
MFCD00047382 | [MOL File]
5122-36-1.mol | [Molecular Weight]
153.14 |
| Chemical Properties | Back Directory | [Melting point ]
224-226 °C | [Boiling point ]
536.1±50.0 °C(Predicted) | [density ]
1.575±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Solid | [pka]
12.35±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3]. | [Definition]
ChEBI: A member of the class of aminopyrimidines that is 4,6-diaminopyrimidine bearing an additional formamido substituent at position 5. A DNA lesion formed when DNA exposed to ionising radiation. | [in vivo]
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. DOI:10.1046/j.1471-4159.1998.71052034.x
[2] Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. DOI:10.1515/znc-1999-3-414
[3] Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. DOI:10.1046/j.1471-4159.1998.71052034.x |
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